Upper airway patency during apnoea of prematurity.

Upper airway patency during apnoea of prematurity.

Twenty four preterm infants (median birth weight 1120 g and gestation 29 weeks) were studied on 83 occasions by measuring upper airway airflow. Airway patency was detected by the transmission of cardiac impulse up the airway and airway closure by its absence. A total of 309 apnoeas of at least five seconds' duration were recorded. One hundred and eighty (58.0%) were central, 109 (35.5%) mixed, ...

Neuromechanical control of upper airway patency during sleep.

Obstructive sleep apnea is caused by pharyngeal occlusion due to alterations in upper airway mechanical properties and/or disturbances in neuromuscular control. The objective of the study was to determine the relative contribution of mechanical loads and dynamic neuromuscular responses to pharyngeal collapse during sleep. Sixteen obstructive sleep apnea patients and sixteen normal subjects were...

Effects of pentobarbital on upper airway patency during sleep.

We hypothesised that pentobarbital would improve upper airway mechanics based on an increase in latency to arousal and amplitude of the phasic genioglossus electromyogram (EMG), and a decrease in the active upper airway critical closing pressure (P(crit)). 12 healthy subjects received pentobarbital (100 mg) or placebo in a double-blind, crossover protocol. During wakefulness, we measured the ge...

Central mechanisms controlling upper airway patency

Upper airway reflexes and obstructive sleep apnoea.

Reflexes originated from the supralaryngeal airways, larynx and lungs can affect upper airway calibre r 11. Specific receptors at the lnryngeal level have been thought to be involved 12J. N~tsal obstruction in normal men m<\y cause apnoeas allll in addition. more arousals and full awakenings from sleep [3]. The underlying mechanism remains unclear. It was demonstrated that nasal occlusion incre...